DNA fingerprinting prepared using multi-locus DNA probe can provide valuable testing system in cases of disputed parentage. Because DNA-based testing takes the advantage of limitless numbers of VNTRs loci and the highly informative character of
these
markers
A simple approach based on Bayesian Theorem disputed to the highly informative character of these markers.
A simple approach based on Bayesian Theorem is described to the interpretation of the DNA fingerprints in disputed paternity cases that are detected by pV47-2 multilocus probe, including a Korean woman who has sought her biological father
toafamily
consisting of a father and his two child. This paper then outline the analysis of each paternity case and give a numerical exampleas following results ;
1. From band-sharing coefficient(X=0.18) of DNA fingerprints detected by pV47-2 multilocus probe, the probability(r) that a parent will pass on a given DNA fingerprint to an offspring is 0.525.
2. As the biological mother(M), child(C), and alleged father(AF) or random man(RM) exhibit a given DNA fingerprint, paternity index(PI) is 1.298.
3. As alleged father or random man and Child share a given DNA fingerprint, but not M, PI is 5.526.
4. AS the biological mother and child share a given DNA fingerprint, but not alleged father or random man, PI is 0.885.
5. As alleged father or random man only shares a given DNA fingerprint, PI is 0.525, whereas the biological mother only has one, PI is 1.1.
6. As the biological mother and alleged father or random man share a given DNA fingerprint, but not child, PI is 0.526.
7. When the biological mother, child and alleged father or random man do not share a given DNA fingerprint, PI is 1.1.
8. From the above paternity indices, likelihood ratio (LR) in case 1 is 99.94?%, LR for child 1 and 2 in case 2 is 99.997% and 99.999%,respectively, but LR for unknown female in case 3 is 62,589% whereas LR for child 1 and 2 is 99.996% and
99.928%,
respectively.
|